Dendritic Tiling
نویسندگان
چکیده
منابع مشابه
Dendritic tiling through TOR signalling.
In many sensory systems, dendrites of sensory neurons cover an entire sensory field in a complete and nonredundant manner, a phenomenon called dendritic tiling. Previous studies have identified the Tricornered (Trc) kinase as an important regulator of this process. In this issue of The EMBO Journal, Koike-Kumagai et al (2009) found that the target of rapamycin (TOR) complex 2 (TORC2) is essenti...
متن کاملDendritic Tiling New Insights from Genetics
Two papers in the current issues of Neuron (Gallegos and Bargmann) and Cell (Emoto et al.) identify a conserved kinase, SAX-1/Trc, and a large protein required for Trc activity, SAX-2/Fry, as essential elements in the control of dendritic branching and tiling in Drosophila and C. elegans. The tiling and ectopic branching phenotypes of trc mutants appear to be independently generated. Thus, this...
متن کاملLike Poles Repel Molecular Mechanisms of Dendritic Tiling
To cover the entire sensory field once and only once, dendrites of some sensory system neurons avoid crossing other dendrites from the same type of neurons. In this issue of Cell, provide first insight into the molecular mechanisms of dendritic tiling.
متن کاملDSCAM-mediated control of dendritic and axonal arbor outgrowth enforces tiling and inhibits synaptic plasticity.
Mature mammalian neurons have a limited ability to extend neurites and make new synaptic connections, but the mechanisms that inhibit such plasticity remain poorly understood. Here, we report that OFF-type retinal bipolar cells in mice are an exception to this rule, as they form new anatomical connections within their tiled dendritic fields well after retinal maturity. The Down syndrome cell-ad...
متن کاملTORC2 controls dendritic tiling of Drosophila sensory neurons via the Tricornered kinase signaling
Thank you for submitting your manuscript to the EMBO Journal. Please find enclosed the comments of two of the three reviewers whom we had asked to evaluate your manuscript for EMBO Journal. We are still waiting for a third report, but given the present majority recommendation I can make a preliminary decision now to save time. This decision is still subject to change should the third referee of...
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ژورنال
عنوان ژورنال: Neuron
سال: 2004
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2004.09.024